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Cytodrox - An antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.
Indication: For management of melanoma, resistant chronic myelocytic leukemia, and recurrent, metastatic, or inoperable carcinoma of the ovary and Sickle-cell anemia.
Cytodrox has dose-dependent synergistic activity with cisplatin in vitro. In vivo Cytodrox showed activity in combination with cisplatin against the LX-1 and CALU-6 human lung xenografts, but minimal activity was seen with the NCI-H460 or NCI-H520 xenografts. Cytodrox was synergistic with cisplatin in the Lewis lung murine xenograft. Sequential exposure to Cytodrox 4 hours before cisplatin produced the greatest interaction.
Pharmaceutical active ingredients containing related brand and generic drugs, medications or other health care products: