There are contraindications! Be sure to consult your doctor before taking any medication!
Ornade consists of Cinnarizine, Isopropamide Iodide, Phenylpropanolamine Hydrochloride.
Cinnarizine - Ornade (Cinnarizine) is an anti-histaminic drug which is mainly used for the control of vomiting due to motion sickness. Ornade (Cinnarizine) was first synthesized by Janssen Pharmaceutica in 1955.It acts by interfering with the signal transmission between vestibular apparatus of the inner ear and the vomiting centre of the hypothalamus. The disparity of signal processing between inner ear motion receptors and the visual senses is abolished, so that the confusion of brain whether the individual is moving or standing is reduced. Vomiting in motion sickness is actually a physiological compensatory mechanism of the brain to keep the individual from moving so that it can adjust to the signal perception. Cinnarizine could be also viewed as a nootropic drug because of its vasorelaxating abilities (due to calcium channel blockage), which happen mostly in brain. It is also effectively combined with other nootropics, primarily piracetam; in such combination each drug potentiate the other in boosting brain oxygen supply.
Indication: For the treatment of vertigo/meniere's disease, nausea and vomiting, motion sickness and also useful for vestibular symptoms of other origins.
Ornade (Cinnarizine) is an antihistamine and a calcium channel blocker. Histamines mediate a number of activities such as contraction of smooth muscle of the airways and gastrointestinal tract, vasodilatation, cardiac stimulation, secretion of gastric acid, promotion of interleukin release and chemotaxis of eosinophils and mast cells. Competitive antagonists at histamine H1 receptors may be divided into first (sedating) and second (non-sedating) generation agents. Some, such as Ornade (Cinnarizine) also block muscarinic acetylcholine receptors and are used as anti-emetic agents. Ornade (Cinnarizine) through its calcium channel blocking ability also inhibits stimulation of the vestibular system.
Phenylpropanolamine Hydrochloride - Ornade (Phenylpropanolamine Hydrochloride) has been withdrawn in Canada. In November 2000, the Food and Drug Administration (FDA) issued a public health advisory against the use of the drug.
Indication: For the treatment of nasal congestion, control of urinary incontinence, priapism and obesity.
Ornade (Phenylpropanolamine Hydrochloride) (PPA), a sympathomimetic agent structurally similar to pseudoephedrine, is used to treat nasal congestion. Ornade (Phenylpropanolamine Hydrochloride) is found in appetite suppressant formulations and with guaifenesinin in cough-cold formulations. In 2000, the FDA requested that all drug companies discontinue marketing products containing phenylpropanolamine, due to an increased risk of hemorrhagic stroke in women who used phenylpropanolamine.
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