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Butrum - A synthetic morphinan analgesic with narcotic antagonist action. It is used in the management of severe pain.
Indication: For the relief of moderate to severe pain.
Butrum is a synthetic opioid agonist-antagonist analgesic with a pharmacological and therapeutic profile that has been well established since its launch as a parenteral formulation in 1978. The introduction of a transnasal formulation of Butrum represents a new and noninvasive presentation of an analgesic for moderate to severe pain. This route of administration bypasses the gastrointestinal tract, and this is an advantage for a drug such as Butrum that undergoes significant first-pass metabolism after oral administration. The onset of action and systemic bioavailability of Butrum following transnasal delivery are similar to those after parenteral administration. Butrum blocks pain impulses at specific sites in the brain and spinal cord.
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