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Cuvarlix
Cuvarlix - Cuvarlix is a drug designed to treat obesity. Its primary function is preventing the absorption of fats from the human diet, thereby reducing caloric intake. Cuvarlix works by inhibiting pancreatic lipase, an enzyme that breaks down triglycerides in the intestine. Without this enzyme, triglycerides from the diet are prevented from being hydrolyzed into absorbable free fatty acids and are excreted undigested.
Indication: For obesity management including weight loss and weight maintenance when used in conjunction with a reduced-calorie diet. Also used to reduce the risk for weight regain after prior weight loss. Use of Cuvarlix is pending revision due to reports of liver-related adverse events.
Cuvarlix is a lipase inhibitor for obesity management that acts byinhibiting the absorption of dietary fats. At the recommendedtherapeutic dose of 120 mg three times a day, Cuvarlix inhibitsdietary fat absorption by approximately 30%. It works by inhibiting pancreatic lipase, an enzyme that breaks down fat in the intestine. Without this enzyme, fat from the diet is excretedundigested and not absorbed by the body. Because some vitamins are fat soluble, the effect of Cuvarlix is to reduce their bodyabsorption. Therefore the drug should only be taken in conjuction with fatty meals, and a multivitamin tablet containing these vitamins (D E K and beta-carotene) should be taken once a day, at least 2 hours before or after taking the drug. In the March 15, 2004 issue of Cancer Research, [1] Steven J. Kridel et al. state that Cuvarlix may also inhibit growth of prostate cancer, and in theory may be useful in treating other cancers, by interfering with the metabolism of fats.
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