There are contraindications! Be sure to consult your doctor before taking any medication!
Dilapan is an antifungal drug from the group of triazole derivatives. Inhibits the synthesis of ergosterol disrupting the permeability of the cell wall. This medication is active against Candida, Microsporum, Cryptococcus neoformans, Trichophyton.
Dilapan is well absorbed after oral administration. Simultaneous ingestion does not affect absorption. The bioavailability is 90%. Dilapan is widely distributed in tissues and organs of the body. Its concentration in breast milk, joint fluid, saliva, sputum, vaginal secretions and peritoneal fluid are similar to those in blood plasma. The concentration in the cerebrospinal fluid is 50-90% of the level in blood plasma, regardless of the presence of inflammation of the meninges. In the stratum corneum, epidermis, dermis and sweat fluid concentrations reach values exceeding the concentration in blood plasma. T1/2 is 30 h. Dilapan is excreted by the kidneys, 80% of the administered dose in an unmodified form.
Why is Dilapan prescribed?
Cryptococcosis (including cryptococcal meningitis), systemic candidiasis, candidiasis of the mucous membranes, vaginal candidiasis, prevention of fungal infections in patients with lowered immunity (including AIDS patients). Fungal infections of skin, including athlete's foot, body, groin, pityriasis versicolor, onychomycosis. Deep endemic mycoses, including coccidioidomycosis, paracoccidioidomycosis, sporotrichosis and histoplasmosis in patients with normal immunity.
Dosage and administration
Dosing regimen of Dilapan is individual. This medication is prescribed for oral and IV administration. Depending on the testimony of the daily dose is 50-400 mg, the multiplicity of application is 1 times / day. If impaired renal function the dose of Dilapan should be reduced.
Pregnancy, children up to age 1 year, increased sensitivity to Dilapan and triazole compounds.
Using during pregnancy and breastfeeding
Dilapan is contraindicated during pregnancy and lactation.
If necessary using this medication during lactation it should solve the issue of termination of breastfeeding. Category effects on the fetus by FDA - C.
Dilapan should be used with caution in patients with severe impaired liver or kidney diseases.
Therapy can be started before the results of seeding and other laboratory tests. However, an anti-infective therapy should be corrected accordingly when the results of these studies will be known.
Dilapan drug interactions
Simultaneous administration of Dilapan with:
coumarin anticoagulants marked increase in prothrombin time.
rifampicin observed shortening of the half-life of fluconazole. Dilapan increases the half-life of oral hypoglycemic agents - sulfonylureas (chlorpropamide, glibenclamide, glipizide, tolbutamide) in healthy people. Simultaneous use of Dilapan and oral hypoglycemic agents in diabetic patients is allowed, however, the physician should bear in mind the possibility of hypoglycemia.
Dilapan in case of emergency / overdose
Symptoms: nausea, vomiting, diarrhea and seizures in severe cases.
Treatment: gastric lavage, forced diuresis, hemodialysis (three-hour dialysis reduces the plasma concentrations of approximately 50%), symptomatic therapy.
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