There are contraindications! Be sure to consult your doctor before taking any medication!

Dilapan

Dilapan

Pharmacological action

Dilapan is an antifungal drug from the group of triazole derivatives. Inhibits the synthesis of ergosterol disrupting the permeability of the cell wall. This medication is active against Candida, Microsporum, Cryptococcus neoformans, Trichophyton.

Pharmacokinetics

Dilapan is well absorbed after oral administration. Simultaneous ingestion does not affect absorption. The bioavailability is 90%. Dilapan is widely distributed in tissues and organs of the body. Its concentration in breast milk, joint fluid, saliva, sputum, vaginal secretions and peritoneal fluid are similar to those in blood plasma. The concentration in the cerebrospinal fluid is 50-90% of the level in blood plasma, regardless of the presence of inflammation of the meninges. In the stratum corneum, epidermis, dermis and sweat fluid concentrations reach values exceeding the concentration in blood plasma. T_1/2 is 30 h. Dilapan is excreted by the kidneys, 80% of the administered dose in an unmodified form.

Why is Dilapan prescribed?

Cryptococcosis (including cryptococcal meningitis), systemic candidiasis, candidiasis of the mucous membranes, vaginal candidiasis, prevention of fungal infections in patients with lowered immunity (including AIDS patients). Fungal infections of skin, including athlete's foot, body, groin, pityriasis versicolor, onychomycosis. Deep endemic mycoses, including coccidioidomycosis, paracoccidioidomycosis, sporotrichosis and histoplasmosis in patients with normal immunity.

Dosage and administration

Dosing regimen of Dilapan is individual. This medication is prescribed for oral and IV administration. Depending on the testimony of the daily dose is 50-400 mg, the multiplicity of application is 1 times / day. If impaired renal function the dose of Dilapan should be reduced.

Dilapan side effects, adverse reactions

Digestive system: nausea, abdominal pain, diarrhea, flatulence.

CNS: headache, dizziness.

Allergic reactions: skin rash, anaphylactic reactions.

Dilapan contraindications

Pregnancy, children up to age 1 year, increased sensitivity to Dilapan and triazole compounds.

Using during pregnancy and breastfeeding

Dilapan is contraindicated during pregnancy and lactation.

If necessary using this medication during lactation it should solve the issue of termination of breastfeeding. Category effects on the fetus by FDA - C.

Special instructions

Dilapan should be used with caution in patients with severe impaired liver or kidney diseases.

Therapy can be started before the results of seeding and other laboratory tests. However, an anti-infective therapy should be corrected accordingly when the results of these studies will be known.

Dilapan drug interactions

Simultaneous administration of Dilapan with: