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Neogadine
Neogadine consists of Magnesium Chloride, Manganese Sulfate, Peptone Iodised, Sodium Metavanadate, Vitamin B12 (Cyanocobalamin), Vitamin B3 (Nicotinamide), Vitamin B6 (Pyridoxine Hydrochloride), Zinc Sulfate. Magnesium Chloride - This medication is a mineral supplement used to prevent and treat low amounts of Neogadine (Magnesium Chloride) in the blood. Neogadine (Magnesium Chloride) is very important for the normal functioning of cells, nerves, muscles, bones, and the heart. Usually, a well- balanced diet provides normal blood levels of magnesium. However, certain situations cause your body to lose Neogadine (Magnesium Chloride) faster than you can replace it from your diet. These situations include treatment with "water pills" (diuretics such as furosemide, hydrochlorothiazide ), a poor diet, alcoholism, or other medical conditions (e.g., severe diarrhea / vomiting, stomach /intestinal absorption problems, poorly controlled diabetes ). Vitamin B12 (Cyanocobalamin) Pharmacological action Neogadine (Vitamin B12 (Cyanocobalamin)) refers to a group of water-soluble vitamins. It has high biological activity. Neogadine (Vitamin B12 (Cyanocobalamin)) is necessary for normal hematopoiesis (promotes maturation of erythrocytes). Involved in the processes of transmethylation, hydrogen transport, synthesis of methionine, nucleic acids, choline, creatine. Contributes to the accumulation in erythrocytes of compounds containing sulfhydryl groups. Has a beneficial effect on liver function and the nervous system. Activates the coagulation of blood in high doses causes an increase in the activity of thromboplastin and prothrombin. Pharmacokinetics After oral administration Neogadine (Vitamin B12 (Cyanocobalamin)) absorbed from the gastrointestinal tract. Metabolized in the tissues, becoming a co-enzyme form - adenosylcobalamin which is the active form of cyanocobalamin. Excreted in bile and urine. Why is Neogadine (Vitamin B12 (Cyanocobalamin)) prescribed? Anemia due to B12-deficiency conditions; in the complex therapy for iron and posthemorrhagic anemia; aplastic anemia caused by toxic substances and drugs; liver disease (hepatitis, cirrhosis); funicular myelosis; polyneuritis, radiculitis, neuralgia, amyotrophic lateral sclerosis; children cerebral palsy, Down syndrome, peripheral nerve injury; skin diseases (psoriasis, photodermatosis, herpetiformis dermatitis, neurodermatitis); to prevent and treat symptoms of deficiency of Neogadine (Vitamin B12 (Cyanocobalamin)) (including the application of biguanide, PASA, vitamin C in high doses); radiation sickness. Dosage and administration Neogadine (Vitamin B12 (Cyanocobalamin)) is used as injections SC, IV, IM, intralumbar, and also oral. With anemia associated with Neogadine (Vitamin B12 (Cyanocobalamin)) deficiency is introduced on 100-200 mcg in 2 days. In anemia with symptoms of funicular myelosis and megalocytic anemia with diseases of the nervous system - 400-500 micrograms in the first 7 days daily, then 1 time every 5-7 days. In the period of remission in the absence of events funicular myelosis maintenance dose - 100 mcg 2 times a month, in the presence of neurological symptoms - at 200-400 mcg 2-4 times a month. In acute post-hemorrhagic anemia and iron anemia by 30-100 mcg 2-3 times a week. When aplastic anemia (especially in children) - 100 micrograms before clinical improvement. When nutritional anemia in infants and preterm - 30 mcg / day during 15 days. In diseases of the central and peripheral nervous system and neurological diseases with a pain syndrome is administered in increasing doses - 200-500 mcg, with the improvement in the state - 100 mcg / day. The course of treatment with Neogadine (Vitamin B12 (Cyanocobalamin)) is 2 weeks. In traumatic lesions of peripheral nervous system - at 200-400 mcg every other day for 40-45 days. When hepatitis and cirrhosis - 30-60 mcg / day or 100 mg every other day for 25-40 days. Dystrophy in young children, Down syndrome and cerebral palsy - by 15-30 mcg every other day. When funicular myelosis, amyotrophic lateral sclerosis can be introduced into the spinal canal at 15-30 mcg, gradually increasing the dose of 200-250 micrograms. In radiation sickness, diabetic neuropathy, sprue - by 60-100 mcg daily for 20-30 days. When deficiency of Neogadine (Vitamin B12 (Cyanocobalamin)) to prevent - IV or IM for 1 mg 1 time a month; for treatment - IV or IM for 1 mg daily for 1-2 weeks, the maintenance dose is 1-2 mg IV or IM from 1 per week, up to 1 per month. Duration of treatment is determined individually. Neogadine (Vitamin B12 (Cyanocobalamin)) side effects, adverse reactions CNS: rarely - a state of arousal. Cardiovascular system: rarely - pain in the heart, tachycardia. Allergic reactions: rarely - urticaria. Neogadine (Vitamin B12 (Cyanocobalamin)) contraindications Thromboembolism, erythremia, erythrocytosis, increased sensitivity to cyanocobalamin. Neogadine (Vitamin B12 (Cyanocobalamin)) using during pregnancy and breastfeeding Cyanocobalamin can be used in pregnancy according to prescriptions. Special instructions When stenocardia should be used with caution in a single dose of Neogadine (Vitamin B12 (Cyanocobalamin)) 100 mcg. During treatment should regularly monitor the blood picture and coagulation. It is unacceptable to enter in the same syringe with cyanocobalamin solutions of thiamine and pyridoxine. Neogadine (Vitamin B12 (Cyanocobalamin)) drug interactions In an application of Neogadine (Vitamin B12 (Cyanocobalamin)) with hormonal contraceptives for oral administration may decrease the concentration of cyanocobalamin in plasma. In an application with anticonvulsant drugs decreased cyanocobalamin absorption from the gut. In an Neogadine (Vitamin B12 (Cyanocobalamin)) application with neomycin, aminosalicylic acid, colchicine, cimetidine, ranitidine, drugs potassium decreased cyanocobalamin absorption from the gut. Cyanocobalamin may exacerbate allergic reactions caused by thiamine. When parenteral application of chloramphenicol may decrease the hematopoietic effects of cyanocobalamin with anemia. Pharmaceutical incompatibility Contained in the molecule of cyanocobalamin cobalt ion contributes to the destruction of ascorbic acid, thiamine bromide, riboflavin in one solution. Zinc Sulfate - A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Neogadine (Zinc Sulfate) deficiency is associated with anemia, short stature, hypogonadism, impaired wound healing, and geophagia. It is known by the symbol Zn.
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