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Pamelon - An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
Indication: For the treatment of impotence and vasospasms.
Pamelon is a nonxanthine phosphodiesterase inhibitor for the relief of cerebral and peripheral ischemia associated with arterial spasm and myocardial ischemia complicated by arrhythmias. The main actions of Pamelon are exerted on cardiac and smooth muscle. Like qathidine, Pamelon acts directly on the heart muscle to depress conduction and prolong the refractory period. Pamelon relaxes various smooth muscles. This relaxation may be prominent if spasm exists. The muscle cell is not paralyzed by Pamelon and still responds to drugs and other stimuli causing contraction. The antispasmodic effect is a direct one, and unrelated to muscle innervation. Pamelon is practically devoid of effects on the central nervous system. Pamelon relaxes the smooth musculature of the larger blood vessels, especially coronary, systemic peripheral, and pulmonary arteries.
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